About the Smith Lab for Pulmonary Immunotoxicology
The overarching focus of my laboratory’s NIEHS funded research is to investigate signaling mechanisms driving sexual dimorphism in lung disease caused by inhalation of air pollutants and other respiratory hazards. Present studies are focused on investigating a role for estrogen receptor alpha (ERa) signaling mechanisms in regulating macrophage activation in response to ozone exposure. These experiments utilize techniques including flow cytometry, live cell bioenergetic measurements, single-cell RNA-sequencing, lung function analyses, and histopathological assessments to investigate the role of various inflammatory signaling mechanisms in wild type and transgenic mouse models.
