About the Smith Lab for Pulmonary Immunotoxicology
The overarching focus of my laboratory’s NIEHS funded research is to investigate signaling mechanisms driving sexual dimorphism in lung disease caused by inhalation of air pollutants and other respiratory hazards. Present studies are focused on investigating a role for estrogen receptor alpha (ERa) signaling mechanisms in regulating macrophage activation in response to ozone exposure. These experiments utilize techniques including flow cytometry, live cell bioenergetic measurements, single-cell RNA-sequencing, lung function analyses, and histopathological assessments to investigate the role of various inflammatory signaling mechanisms in wild type and transgenic mouse models.
Dr. Mohankumar is the recipient of the prestigious Young Achiever Award from the Associate of Pharmacy Professionals for his achievements in investigating emerging trends and opportunities in drug discovery and development. Congratulations Mohan!
Dr. Smith was recently profiled by Toxicological Sciences alongside his recently published manuscript being featured as a ToxSpotlight article. Learn more about Dr. Smith in the author profile found here and follow this link to read the manuscript.
A recently published manuscript from the Smith Lab for Pulmonary Immunotoxicology titled “Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation” was featured in the latest issue of Toxicological Sciences! Learn more here: https://doi.org/10.1093/toxsci/kfae081.
