Dr. Smith’s Manuscript Featured in Toxicological Sciences

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Dr. Smith's recently published manuscript titled, "Role of PPARγ in dyslipidemia and altered pulmonary functioning in mice following ozone exposure" was highlighted as a featured article in the July issue of Toxicological Sciences. In this manuscript, Dr. Smith and his co-authors found that administration of a PPARγ agonist (rosiglitazone) restored normal pulmonary function and decreased pulmonary lipids (PL) in ozone-exposed mice. These results highlight the importance of alveolar lipids and point to a critical role for alveolar macrophages (AM) in regulating surfactant activity and lung function after ozone.

Hypothetical Model

Inhalation of ozone disrupts lung lipid homeostasis by increasing surfactant production by alveolar epithelial type II (ATII) cells and reducing lipid uptake by alveolar macrophages (AM); this leads to an imbalance in the levels of surfactant protein B (SP-B) and phospholipids (PL) which results in decrements in lung function. Administration of the PPARγ agonist, rosiglitazone, increases expression of the lipid scavenger receptor, Cd36, which enhances clearance of excess lipids; this normalizes relative SP-B to phospholipid levels and pulmonary function. Created with Biorender.